Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EA_STRING Exclusive	Literature	7.83e-05	1.78e-04	1.38e-04	8.09e-08
Literature Exclusive	EA_STRING	1.72e-03	2.76e-04	2.04e-11	1.11e-04
EA_STRING Exclusive	Literature Exclusive	1.21e-03	1.12e-03	2.68e-03	9.77e-07
Literature Exclusive	EA_STRING Exclusive	2.06e-03	4.27e-04	1.67e-11	1.61e-04
EA_STRING Exclusive	Overlap	1.60e-03	5.52e-03	1.53e-03	2.13e-03
Literature Exclusive	Overlap	1.38e-03	1.38e-03	1.38e-03	1.38e-03
Overlap	Exclusives	1.79e-25	3.90e-23	2.44e-75	4.57e-23



Evaluating how well EA_STRING genes are linked to Literature genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA_STRING Exclusive	Literature	0.72	1.00	3.49	1.47	6.18
Literature Exclusive	EA_STRING	0.56	3.44	5.99	2.28	4.77
EA_STRING Exclusive	Literature Exclusive	0.70	0.65	3.21	0.66	5.17
Literature Exclusive	EA_STRING Exclusive	0.55	2.97	5.36	2.62	4.54
EA_STRING Exclusive	Overlap	0.98	2.72	2.40	3.05	2.81
Literature Exclusive	Overlap	1.00	3.69	2.69	3.04	3.01
Overlap	Exclusives	0.63	3.20	13.67	3.16	11.73

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA_STRING Exclusive	Literature	0.01	3.12	1.59	4.46	12.91
Literature Exclusive	EA_STRING	0.04	4.58	7.22	2.38	5.03
EA_STRING Exclusive	Literature Exclusive	0.01	2.16	1.53	2.58	6.66
Literature Exclusive	EA_STRING Exclusive	0.04	3.62	4.66	2.51	3.62
EA_STRING Exclusive	Overlap	0.00	6.24	8.16	16.19	0.80
Literature Exclusive	Overlap	0.09	126.81	281.42	276.34	239.54
Overlap	Exclusives	0.08	11.09	40.22	9.51	39.98

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EA_STRING Exclusive	614	608	UGT2A1;PTGES3L-AARSD1;PAGR1;MRPL23;ZNF816-ZNF321P;GIMAP1-GIMAP5
Literature Exclusive	60	55	CDKN2BAS1;RALI;PSCK9;ZNF259;LPAL2
Overlap	3	3