Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI	Viral	1.09e-01	1.36e-02	1.19e-01	2.01e-10
Viral	EPI	1.22e-05	1.74e-01	1.34e-02	1.94e-01



Evaluating how well EPI genes are linked to Viral genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI	Viral	0.71	1.19	3.83	1.15	7.52
Viral	EPI	0.53	3.13	1.53	1.87	1.72

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI	Viral	0.01	0.52	3.33	0.74	3.64
Viral	EPI	0.01	2.92	0.32	0.90	0.57

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI	185	178	FMC1;CFAP157;PNMA8B;DRC3;BICRA;ANOS1;LOC100505841
Viral	108	104	MBL3P;HLA-DRB4;SNORA31;SRY