Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI	Covid	1.66e-01	1.08e-01	4.91e-01	8.45e-07
Covid	EPI	9.29e-05	2.29e-01	2.53e-02	4.15e-01



Evaluating how well EPI genes are linked to Covid genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI	Covid	0.70	0.98	2.23	0.53	7.06
Covid	EPI	0.52	3.77	1.30	1.05	1.20

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI	Covid	0.01	1.02	2.71	0.28	8.73
Covid	EPI	0.01	2.69	0.16	0.52	0.21

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI	185	178	FMC1;CFAP157;BICRA;DRC3;LOC100505841;ANOS1;PNMA8B
Covid	78	75	HLA-DRB4;SRY;MBL3P