Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI	JLC	2.42e-01	2.46e-01	3.22e-01	5.50e-02
JLC	EPI	9.12e-06	4.72e-01	1.09e-02	7.55e-01



Evaluating how well EPI genes are linked to JLC genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI	JLC	0.74	0.54	1.74	0.36	2.91
JLC	EPI	0.52	2.32	1.40	1.03	0.91

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI	JLC	0.00	0.16	2.73	0.29	3.80
JLC	EPI	0.01	1.98	0.92	0.38	0.43

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI	185	178	ANOS1;FMC1;PNMA8B;BICRA;CFAP157;DRC3;LOC100505841
JLC	13	10	TRIF;NEMO;UNC93B