Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI	JLC	1.41e-01	5.60e-02	6.11e-02	2.31e-03
JLC	EPI	7.42e-05	6.73e-01	7.53e-03	9.15e-01



Evaluating how well EPI genes are linked to JLC genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI	JLC	0.80	0.54	2.12	0.95	3.40
JLC	EPI	0.51	1.85	0.79	0.99	0.28

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI	JLC	0.00	-0.15	1.83	0.12	2.40
JLC	EPI	0.01	1.13	0.34	0.25	0.15

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI	216	202	ADGRE2;PLPP7;LOC100505841;PLPPR2;FMC1;DRC7;MFSD4A;WASHC2C;ADGRE1;ADGRF5;ERBIN;KCNE5;PRICKLE4;MAP3K20
JLC	13	10	UNC93B;TRIF;NEMO