Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI	Viral	5.11e-02	1.23e-02	2.99e-02	6.43e-14
Viral	EPI	4.09e-11	8.94e-01	4.40e-03	8.21e-01



Evaluating how well EPI genes are linked to Viral genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI	Viral	0.73	1.06	3.58	1.17	7.67
Viral	EPI	0.50	0.90	-0.09	0.18	-0.11

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI	Viral	0.01	0.13	2.65	0.34	9.04
Viral	EPI	0.01	1.89	0.37	0.56	0.37

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI	216	202	ERBIN;ADGRE2;PLPP7;MFSD4A;DRC7;KCNE5;ADGRF5;FMC1;WASHC2C;ADGRE1;PLPPR2;LOC100505841;PRICKLE4;MAP3K20
Viral	108	104	MBL3P;SRY;HLA-DRB4;SNORA31