Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML	JLC	3.22e-01	5.95e-01	3.31e-01	9.17e-03
JLC	EAML	2.36e-02	1.67e-01	9.11e-03	3.91e-02



Evaluating how well EAML genes are linked to JLC genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML	JLC	0.72	0.71	0.81	0.32	2.68
JLC	EAML	0.56	0.82	0.98	1.40	1.31

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML	JLC	0.00	0.79	3.13	0.68	7.28
JLC	EAML	0.00	0.92	0.35	0.06	0.71

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML	51	49	PNMA8A;ANOS1
JLC	13	10	NEMO;TRIF;UNC93B