Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML	Viral	8.63e-01	7.18e-01	1.15e-01	2.03e-06
Viral	EAML	1.75e-03	5.68e-01	1.85e-01	1.32e-01



Evaluating how well EAML genes are linked to Viral genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML	Viral	0.66	-0.01	-0.70	0.25	5.91
Viral	EAML	0.55	0.32	0.38	0.89	1.18

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML	Viral	0.01	0.36	0.66	0.34	2.82
Viral	EAML	0.00	-0.38	-0.19	0.57	0.25

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML	51	49	ANOS1;PNMA8A
Viral	108	104	SRY;MBL3P;SNORA31;HLA-DRB4