Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML	JLC	8.16e-01	1.83e-01	5.95e-01	4.27e-02
JLC	EAML	5.07e-03	9.93e-01	1.59e-01	9.79e-01



Evaluating how well EAML genes are linked to JLC genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML	JLC	0.75	0.32	1.34	0.60	2.21
JLC	EAML	0.50	0.08	0.21	0.63	-0.21

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML	JLC	0.00	0.04	0.65	0.07	0.42
JLC	EAML	0.00	0.02	-0.03	0.24	-0.02

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML	67	63	ADGRF3;PLPPR2;CFAP65;KCNE5
JLC	13	10	TRIF;NEMO;UNC93B