Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML	Covid	4.46e-02	2.13e-02	1.11e-01	1.70e-09
Covid	EAML	3.81e-03	1.35e-01	5.87e-01	3.74e-01



Evaluating how well EAML genes are linked to Covid genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML	Covid	0.70	0.83	2.37	0.76	6.66
Covid	EAML	0.51	2.34	0.69	1.04	0.32

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML	Covid	0.01	0.08	1.59	0.11	3.86
Covid	EAML	0.00	0.56	-0.29	-0.04	-0.17

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML	67	63	KCNE5;PLPPR2;CFAP65;ADGRF3
Covid	78	75	MBL3P;HLA-DRB4;SRY