Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML	Viral	2.00e-01	2.95e-02	9.82e-02	1.80e-10
Viral	EAML	2.52e-05	3.58e-01	1.09e-01	2.95e-01



Evaluating how well EAML genes are linked to Viral genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML	Viral	0.68	0.42	2.56	0.65	6.28
Viral	EAML	0.50	1.38	-0.06	0.61	-0.20

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML	Viral	0.01	-0.19	1.89	-0.01	4.21
Viral	EAML	0.00	2.06	-0.14	0.47	-0.11

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML	67	63	ADGRF3;PLPPR2;KCNE5;CFAP65
Viral	108	104	MBL3P;SNORA31;HLA-DRB4;SRY