Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Wave Exclusive	Covid	6.84e-09	7.35e-09	4.65e-36	1.53e-26
Covid Exclusive	Wave	6.65e-09	1.68e-02	1.72e-13	4.50e-16
Wave Exclusive	Covid Exclusive	2.10e-07	6.97e-08	2.13e-33	3.18e-24
Covid Exclusive	Wave Exclusive	1.11e-09	7.06e-02	4.18e-12	1.22e-14
Wave Exclusive	Overlap	9.96e-03	3.41e-02	8.67e-05	1.85e-04
Covid Exclusive	Overlap	2.10e-05	5.87e-05	2.10e-05	3.02e-05
Overlap	Exclusives	1.73e-12	5.20e-11	2.40e-34	1.40e-35



Evaluating how well Wave genes are linked to Covid genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wave Exclusive	Covid	0.86	3.45	7.82	3.16	11.10
Covid Exclusive	Wave	0.72	-3.23	1.46	1.85	10.24
Wave Exclusive	Covid Exclusive	0.85	3.02	7.10	3.58	11.23
Covid Exclusive	Wave Exclusive	0.71	-4.15	0.84	1.81	9.40
Wave Exclusive	Overlap	0.93	2.16	1.69	1.44	3.12
Covid Exclusive	Overlap	1.00	2.45	3.17	2.22	4.02
Overlap	Exclusives	0.77	1.25	6.51	1.90	14.86

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wave Exclusive	Covid	0.02	3.48	7.84	4.82	13.19
Covid Exclusive	Wave	0.03	-0.52	8.78	6.30	13.72
Wave Exclusive	Covid Exclusive	0.02	2.89	7.65	6.55	9.49
Covid Exclusive	Wave Exclusive	0.02	-1.49	4.87	4.24	12.93
Wave Exclusive	Overlap	0.00	0.52	-1.60	1.56	2.16
Covid Exclusive	Overlap	0.04	1.58	50.84	47.79	67.88
Overlap	Exclusives	0.06	5.80	24.40	10.74	46.50

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Wave Exclusive	155	154	CHD2
Covid Exclusive	73	70	SRY;MBL3P;HLA-DRB4
Overlap	5	5