Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Wave	JLC	1.30e-04	2.74e-06	7.43e-10	4.46e-08
JLC	Wave	1.55e-04	8.90e-02	5.52e-05	1.23e-24



Evaluating how well Wave genes are linked to JLC genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wave	JLC	0.97	1.82	4.64	2.14	5.02
JLC	Wave	0.74	2.24	1.80	1.70	10.20

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wave	JLC	0.01	4.43	37.48	15.28	40.49
JLC	Wave	0.02	5.01	3.36	5.02	14.11

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Wave	163	163	
JLC	13	10	TRIF;UNC93B;NEMO