Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
GeneGroup1 Exclusive	GeneGroup2	1.24e-01	6.80e-01	7.02e-02	1.95e-01
GeneGroup2 Exclusive	GeneGroup1	5.37e-01	6.99e-01	9.80e-04	5.77e-01
GeneGroup1 Exclusive	GeneGroup2 Exclusive	2.38e-01	4.54e-01	1.24e-01	2.78e-01
GeneGroup2 Exclusive	GeneGroup1 Exclusive	6.21e-01	8.99e-01	1.23e-03	5.66e-01
GeneGroup1 Exclusive	Overlap	2.92e-01	9.92e-02	2.40e-01	3.51e-01
GeneGroup2 Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	6.85e-03	2.39e-01	7.51e-18	1.99e-01



Evaluating how well GeneGroup1 genes are linked to GeneGroup2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GeneGroup1 Exclusive	GeneGroup2	0.62	-1.12	-0.45	-1.02	1.63
GeneGroup2 Exclusive	GeneGroup1	0.48	1.84	0.80	0.68	-0.56
GeneGroup1 Exclusive	GeneGroup2 Exclusive	0.61	-0.92	-0.87	-0.94	1.24
GeneGroup2 Exclusive	GeneGroup1 Exclusive	0.47	1.63	0.51	0.48	-0.56
GeneGroup1 Exclusive	Overlap	0.78	-0.68	2579287648100135.00	-0.56	1.02
GeneGroup2 Exclusive	Overlap	1.00	1.72	1131782473217415.00	2.14	1.73
Overlap	Exclusives	0.55	inf	2.03	0.77	1.27

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GeneGroup1 Exclusive	GeneGroup2	0.00	0.06	1.55	-0.15	0.70
GeneGroup2 Exclusive	GeneGroup1	0.00	2.62	0.82	0.55	0.66
GeneGroup1 Exclusive	GeneGroup2 Exclusive	0.00	0.15	1.14	0.09	1.34
GeneGroup2 Exclusive	GeneGroup1 Exclusive	0.00	0.57	0.02	-0.15	-0.11
GeneGroup1 Exclusive	Overlap	0.00	-0.65	inf	-0.34	0.05
GeneGroup2 Exclusive	Overlap	0.02	78.14	1310073719520510464.00	83.34	140.45
Overlap	Exclusives	0.01	4971504219513691.00	6.74	5.49	6.77

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
GeneGroup1 Exclusive	49	49	
GeneGroup2 Exclusive	13	12	Parkin
Overlap	1	1