Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral Exclusive	R_Control	5.53e-05	4.78e-03	3.15e-08	1.64e-05
R_Control Exclusive	Viral	2.52e-05	3.24e-09	3.98e-08	1.39e-17
Viral Exclusive	R_Control Exclusive	2.27e-04	1.42e-02	3.77e-07	6.65e-05
R_Control Exclusive	Viral Exclusive	3.16e-04	3.87e-08	4.12e-07	9.05e-15
Viral Exclusive	Overlap	1.69e-04	3.53e-04	1.69e-04	2.69e-04
R_Control Exclusive	Overlap	4.95e-03	7.98e-03	8.13e-04	2.89e-03
Overlap	Exclusives	2.21e-08	1.05e-11	2.81e-29	3.49e-23



Evaluating how well Viral genes are linked to R_Control genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	R_Control	0.61	3.48	4.03	1.63	7.20
R_Control Exclusive	Viral	0.75	2.02	6.84	2.81	8.91
Viral Exclusive	R_Control Exclusive	0.60	3.54	3.74	1.74	5.35
R_Control Exclusive	Viral Exclusive	0.74	1.77	7.20	2.39	7.98
Viral Exclusive	Overlap	0.99	4.35	3.69	3.68	3.41
R_Control Exclusive	Overlap	0.92	2.87	2.52	3.33	3.17
Overlap	Exclusives	0.68	2.06	10.17	1.53	11.41

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	R_Control	0.02	4.69	5.22	2.25	9.67
R_Control Exclusive	Viral	0.01	0.19	8.08	1.50	11.80
Viral Exclusive	R_Control Exclusive	0.02	4.78	4.07	2.01	6.00
R_Control Exclusive	Viral Exclusive	0.01	-0.25	8.52	1.09	4.92
Viral Exclusive	Overlap	0.02	52.44	63.18	51.67	67.39
R_Control Exclusive	Overlap	0.00	3.15	0.85	5.54	2.28
Overlap	Exclusives	0.06	7.55	36.35	5.90	40.75

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral Exclusive	104	100	HLA-DRB4;SNORA31;MBL3P;ABO
R_Control Exclusive	269	264	NAPRT;IZUMO4;MICU2;HYAL3;DEFB133
Overlap	4	4