Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral Exclusive	R_Control	5.78e-05	1.14e-03	4.79e-10	5.56e-08
R_Control Exclusive	Viral	4.46e-03	4.61e-07	1.35e-07	2.24e-17
Viral Exclusive	R_Control Exclusive	1.25e-04	2.02e-03	4.36e-09	5.40e-07
R_Control Exclusive	Viral Exclusive	8.50e-03	1.88e-06	1.09e-06	5.42e-17
Viral Exclusive	Overlap	1.69e-04	1.02e-02	1.69e-04	2.69e-04
R_Control Exclusive	Overlap	1.45e-02	1.30e-01	4.59e-03	2.47e-03
Overlap	Exclusives	6.72e-10	2.61e-14	5.97e-37	5.26e-26



Evaluating how well Viral genes are linked to R_Control genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	R_Control	0.62	2.81	4.81	2.26	7.40
R_Control Exclusive	Viral	0.76	1.19	5.23	2.14	8.90
Viral Exclusive	R_Control Exclusive	0.62	3.39	5.13	2.40	6.65
R_Control Exclusive	Viral Exclusive	0.75	1.15	5.12	1.75	9.94
Viral Exclusive	Overlap	0.99	2.40	2.92	2.71	3.06
R_Control Exclusive	Overlap	0.93	2.25	1.75	2.65	2.89
Overlap	Exclusives	0.71	1.02	11.52	2.14	12.62

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	R_Control	0.02	1.51	5.25	2.04	7.15
R_Control Exclusive	Viral	0.01	-0.53	4.54	0.82	11.80
Viral Exclusive	R_Control Exclusive	0.02	1.37	3.89	1.89	6.96
R_Control Exclusive	Viral Exclusive	0.01	-0.50	3.77	0.44	4.81
Viral Exclusive	Overlap	0.02	7.59	71.15	32.96	31.27
R_Control Exclusive	Overlap	0.00	-0.23	0.61	1.28	0.33
Overlap	Exclusives	0.07	5.41	28.47	6.55	41.11

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral Exclusive	104	100	HLA-DRB4;MBL3P;SNORA31;SRY
R_Control Exclusive	269	269	
Overlap	4	4