Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid Exclusive	R_Control	5.59e-05	4.62e-03	4.39e-10	2.07e-07
R_Control Exclusive	Covid	8.14e-03	6.55e-07	7.95e-08	4.60e-16
Covid Exclusive	R_Control Exclusive	1.15e-04	8.16e-03	1.10e-09	1.28e-07
R_Control Exclusive	Covid Exclusive	1.90e-02	1.05e-06	3.30e-07	7.00e-15
Covid Exclusive	Overlap	9.92e-02	1.18e-01	9.92e-02	1.05e-01
R_Control Exclusive	Overlap	9.92e-02	1.33e-01	9.92e-02	1.33e-01
Overlap	Exclusives	4.94e-13	5.13e-15	2.74e-31	1.24e-26



Evaluating how well Covid genes are linked to R_Control genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	R_Control	0.62	2.86	5.95	2.09	7.55
R_Control Exclusive	Covid	0.78	1.25	5.56	1.87	8.95
Covid Exclusive	R_Control Exclusive	0.62	2.59	4.45	1.99	7.26
R_Control Exclusive	Covid Exclusive	0.78	0.96	5.19	1.69	7.91
Covid Exclusive	Overlap	0.97	1.19	1.80	1.54	1.67
R_Control Exclusive	Overlap	0.96	1.66	1.48	1.51	1.62
Overlap	Exclusives	0.70	1.28	10.43	2.00	13.60

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	R_Control	0.02	1.40	5.85	1.84	7.07
R_Control Exclusive	Covid	0.01	-0.61	5.28	0.62	3.28
Covid Exclusive	R_Control Exclusive	0.02	1.25	4.01	1.54	6.60
R_Control Exclusive	Covid Exclusive	0.01	-0.67	4.39	0.43	13.87
Covid Exclusive	Overlap	0.00	0.06	3.28	1.62	0.31
R_Control Exclusive	Overlap	0.00	1.68	1.62	1.05	1.01
Overlap	Exclusives	0.04	1.51	17.96	2.36	24.41

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid Exclusive	77	74	SRY;MBL3P;HLA-DRB4
R_Control Exclusive	272	272	
Overlap	1	1