Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
JLC Exclusive	R_Control	9.63e-10	6.98e-01	2.39e-03	4.22e-03
R_Control Exclusive	JLC	4.49e-01	1.28e-02	7.10e-03	8.55e-06
JLC Exclusive	R_Control Exclusive	4.71e-10	8.26e-01	1.30e-02	6.34e-03
R_Control Exclusive	JLC Exclusive	6.00e-01	4.48e-02	3.44e-02	5.02e-05
JLC Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
R_Control Exclusive	Overlap	9.92e-02	2.40e-01	9.92e-02	2.06e-01
Overlap	Exclusives	1.22e-05	2.05e-01	3.26e-04	8.12e-05



Evaluating how well JLC genes are linked to R_Control genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC Exclusive	R_Control	0.57	0.71	0.94	0.39	4.55
R_Control Exclusive	JLC	0.83	0.63	2.64	1.24	4.08
JLC Exclusive	R_Control Exclusive	0.57	0.58	0.86	0.23	4.14
R_Control Exclusive	JLC Exclusive	0.83	0.10	2.46	0.84	3.84
JLC Exclusive	Overlap	1.00	2.82	2.27	2.14	1.85
R_Control Exclusive	Overlap	0.90	2.15	1.24	2.78	1.27
Overlap	Exclusives	0.58	0.10	0.86	0.14	4.88

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC Exclusive	R_Control	0.02	0.93	1.49	0.64	4.12
R_Control Exclusive	JLC	0.00	-0.41	1.89	0.39	4.91
JLC Exclusive	R_Control Exclusive	0.02	0.83	1.01	0.40	3.06
R_Control Exclusive	JLC Exclusive	0.00	-0.54	1.93	-0.07	1.48
JLC Exclusive	Overlap	0.04	1342.82	795.42	130.41	39.92
R_Control Exclusive	Overlap	0.00	2.99	-0.03	7.24	0.16
Overlap	Exclusives	0.03	1.34	10.42	1.68	18.72

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
JLC Exclusive	12	11	UNC93B
R_Control Exclusive	272	272	
Overlap	1	1