Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
JLC	R_Control	4.80e-11	5.40e-01	6.54e-02	2.76e-03
R_Control	JLC	1.05e-01	1.69e-02	6.32e-05	1.83e-04



Evaluating how well JLC genes are linked to R_Control genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	R_Control	0.60	-0.54	-0.53	0.11	4.32
R_Control	JLC	0.83	0.70	2.63	1.44	3.79

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	R_Control	0.01	0.08	0.42	0.27	2.36
R_Control	JLC	0.00	-0.33	1.73	0.43	2.71

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
JLC	13	12	UNC93B
R_Control	148	148