Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid	R_Control	4.12e-04	1.51e-01	2.61e-04	2.86e-06
R_Control	Covid	1.39e-01	2.94e-02	8.40e-04	5.31e-10



Evaluating how well Covid genes are linked to R_Control genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	R_Control	0.63	0.99	2.33	1.42	5.78
R_Control	Covid	0.71	0.08	2.17	0.83	6.41

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	R_Control	0.01	-0.46	0.98	0.66	1.71
R_Control	Covid	0.01	-0.78	0.95	0.13	4.63

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid	78	75	HLA-DRB4;SRY;MBL3P
R_Control	148	148