Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral Exclusive	R_Control	2.60e-05	1.05e-01	1.28e-05	1.14e-05
R_Control Exclusive	Viral	6.70e-03	3.62e-02	2.93e-04	5.36e-11
Viral Exclusive	R_Control Exclusive	6.72e-05	1.48e-01	5.12e-05	1.51e-05
R_Control Exclusive	Viral Exclusive	1.07e-02	2.52e-02	7.98e-05	3.24e-11
Viral Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
R_Control Exclusive	Overlap	1.25e-01	4.17e-01	9.92e-02	1.33e-01
Overlap	Exclusives	3.02e-14	1.91e-13	2.93e-45	8.94e-27



Evaluating how well Viral genes are linked to R_Control genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	R_Control	0.63	0.97	2.58	1.48	4.85
R_Control Exclusive	Viral	0.70	-0.20	1.80	0.80	6.98
Viral Exclusive	R_Control Exclusive	0.63	1.12	2.14	1.56	5.88
R_Control Exclusive	Viral Exclusive	0.70	0.01	1.80	1.20	7.14
Viral Exclusive	Overlap	1.00	1.47	3.34	1.54	1.86
R_Control Exclusive	Overlap	0.94	0.06	1.13	0.98	1.50
Overlap	Exclusives	0.74	1.22	8.28	1.88	12.83

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	R_Control	0.01	-0.59	1.43	1.25	3.79
R_Control Exclusive	Viral	0.01	-0.70	0.67	0.16	2.92
Viral Exclusive	R_Control Exclusive	0.01	-0.59	0.90	1.10	3.97
R_Control Exclusive	Viral Exclusive	0.01	-0.66	0.38	0.81	7.58
Viral Exclusive	Overlap	0.01	12.86	145.85	41.02	77.04
R_Control Exclusive	Overlap	0.00	-0.31	0.02	0.75	0.62
Overlap	Exclusives	0.06	6.04	31.42	6.26	47.42

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral Exclusive	107	103	SRY;SNORA31;HLA-DRB4;MBL3P
R_Control Exclusive	147	147	
Overlap	1	1