Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
JLC	R_Mild	2.41e-15	1.13e-01	4.07e-01	1.54e-02
R_Mild	JLC	1.02e-01	6.23e-01	2.98e-01	1.43e-01



Evaluating how well JLC genes are linked to R_Mild genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	R_Mild	0.54	-0.98	-1.94	-0.18	1.57
R_Mild	JLC	0.64	-0.30	-0.39	-0.14	1.74

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	R_Mild	0.01	-0.65	-1.21	-0.26	0.17
R_Mild	JLC	0.00	-0.49	-1.01	-0.40	0.28

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
JLC	13	12	UNC93B
R_Mild	139	139