Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid Exclusive	R_Mild	1.02e-03	2.41e-02	1.57e-04	5.85e-06
R_Mild Exclusive	Covid	8.46e-02	2.93e-05	1.64e-03	1.65e-11
Covid Exclusive	R_Mild Exclusive	6.15e-04	3.19e-02	2.62e-04	5.62e-06
R_Mild Exclusive	Covid Exclusive	2.91e-01	2.63e-05	2.62e-03	9.18e-11
Covid Exclusive	Overlap	9.92e-02	1.57e-01	9.92e-02	1.12e-01
R_Mild Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	1.05e-01
Overlap	Exclusives	1.61e-41	2.12e-36	8.99e-41	8.33e-51



Evaluating how well Covid genes are linked to R_Mild genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	R_Mild	0.63	2.42	3.88	1.33	5.68
R_Mild Exclusive	Covid	0.73	0.79	4.13	1.01	7.58
Covid Exclusive	R_Mild Exclusive	0.62	2.25	3.11	1.47	5.24
R_Mild Exclusive	Covid Exclusive	0.72	0.50	3.88	0.99	6.56
Covid Exclusive	Overlap	0.98	1.79	1.74	1.69	1.66
R_Mild Exclusive	Overlap	0.99	1.71	2.00	2.12	1.87
Overlap	Exclusives	0.83	3.01	16.05	2.36	15.90

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	R_Mild	0.01	0.89	2.48	0.87	2.59
R_Mild Exclusive	Covid	0.01	-0.24	3.35	0.17	2.63
Covid Exclusive	R_Mild Exclusive	0.01	1.72	1.78	0.97	3.06
R_Mild Exclusive	Covid Exclusive	0.01	-0.48	2.95	0.11	6.39
Covid Exclusive	Overlap	0.00	2.76	0.13	3.00	2.53
R_Mild Exclusive	Overlap	0.00	3.64	4.55	11.50	7.21
Overlap	Exclusives	0.05	5.07	30.27	4.84	41.58

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid Exclusive	77	74	MBL3P;SRY;HLA-DRB4
R_Mild Exclusive	138	138	
Overlap	1	1