Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral Exclusive	R_Mild	3.77e-07	3.78e-02	6.11e-05	5.05e-04
R_Mild Exclusive	Viral	1.69e-01	2.07e-05	2.18e-03	1.36e-12
Viral Exclusive	R_Mild Exclusive	1.76e-07	4.30e-02	1.23e-04	5.32e-04
R_Mild Exclusive	Viral Exclusive	1.89e-01	6.37e-05	1.05e-02	6.58e-12
Viral Exclusive	Overlap	9.92e-02	1.18e-01	9.92e-02	1.05e-01
R_Mild Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	9.09e-44	3.98e-42	1.07e-59	5.49e-59



Evaluating how well Viral genes are linked to R_Mild genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	R_Mild	0.60	1.88	2.05	1.07	4.32
R_Mild Exclusive	Viral	0.71	0.85	4.90	1.12	8.63
Viral Exclusive	R_Mild Exclusive	0.60	1.48	1.89	1.15	3.90
R_Mild Exclusive	Viral Exclusive	0.71	0.82	4.02	0.74	7.14
Viral Exclusive	Overlap	0.98	2.04	1.76	1.96	1.71
R_Mild Exclusive	Overlap	0.99	1.63	1.95	1.95	1.85
Overlap	Exclusives	0.83	2.61	14.78	2.91	20.06

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	R_Mild	0.01	1.60	2.16	0.86	2.36
R_Mild Exclusive	Viral	0.01	-0.33	3.34	0.11	6.67
Viral Exclusive	R_Mild Exclusive	0.01	1.00	1.61	0.70	2.36
R_Mild Exclusive	Viral Exclusive	0.01	-0.27	2.37	-0.07	5.91
Viral Exclusive	Overlap	0.00	13.71	1.19	7.09	1.03
R_Mild Exclusive	Overlap	0.00	8.35	15.03	8.51	14.78
Overlap	Exclusives	0.06	4.22	38.28	6.26	44.52

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral Exclusive	107	103	SRY;HLA-DRB4;MBL3P;SNORA31
R_Mild Exclusive	138	138	
Overlap	1	1