Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral Exclusive	R_Mild	2.55e-05	3.74e-02	1.52e-05	3.59e-06
R_Mild Exclusive	Viral	2.21e-01	2.00e-02	1.35e-02	1.10e-11
Viral Exclusive	R_Mild Exclusive	1.27e-05	7.15e-02	4.56e-05	6.52e-06
R_Mild Exclusive	Viral Exclusive	3.12e-01	3.30e-02	2.32e-02	3.05e-11
Viral Exclusive	Overlap	1.38e-03	7.88e-02	1.38e-03	2.03e-03
R_Mild Exclusive	Overlap	1.39e-02	5.02e-01	2.13e-03	4.43e-03
Overlap	Exclusives	1.26e-07	3.17e-16	5.50e-73	4.78e-34



Evaluating how well Viral genes are linked to R_Mild genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	R_Mild	0.62	1.44	1.98	1.26	5.88
R_Mild Exclusive	Viral	0.71	0.59	2.90	0.78	7.33
Viral Exclusive	R_Mild Exclusive	0.61	1.31	1.74	1.03	5.35
R_Mild Exclusive	Viral Exclusive	0.70	0.48	2.78	0.80	6.40
Viral Exclusive	Overlap	0.99	1.78	2.11	2.01	3.00
R_Mild Exclusive	Overlap	0.95	1.32	1.59	1.75	2.95
Overlap	Exclusives	0.75	1.49	12.13	1.93	16.17

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	R_Mild	0.01	0.75	1.34	1.13	3.62
R_Mild Exclusive	Viral	0.01	-0.70	0.93	-0.20	5.93
Viral Exclusive	R_Mild Exclusive	0.01	0.47	0.79	0.67	3.13
R_Mild Exclusive	Viral Exclusive	0.01	-0.71	0.57	-0.28	2.24
Viral Exclusive	Overlap	0.01	3.68	13.13	7.27	40.23
R_Mild Exclusive	Overlap	0.00	-0.25	2.99	0.50	4.95
Overlap	Exclusives	0.07	6.08	34.90	6.68	51.43

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral Exclusive	105	101	SNORA31;MBL3P;SRY;HLA-DRB4
R_Mild Exclusive	199	199	
Overlap	3	3