Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid Exclusive	R_Mild	9.55e-04	4.67e-02	9.97e-07	6.06e-07
R_Mild Exclusive	Covid	1.46e-01	1.80e-03	4.19e-04	1.35e-11
Covid Exclusive	R_Mild Exclusive	9.09e-04	8.04e-02	6.42e-06	1.25e-06
R_Mild Exclusive	Covid Exclusive	2.43e-01	3.92e-03	3.77e-04	1.87e-12
Covid Exclusive	Overlap	9.92e-02	1.41e-01	9.92e-02	1.05e-01
R_Mild Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	1.07e-26	8.46e-26	1.15e-41	8.72e-41



Evaluating how well Covid genes are linked to R_Mild genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	R_Mild	0.63	1.90	2.78	1.45	6.65
R_Mild Exclusive	Covid	0.74	0.40	4.14	1.23	7.23
Covid Exclusive	R_Mild Exclusive	0.63	2.03	2.26	1.33	6.42
R_Mild Exclusive	Covid Exclusive	0.74	0.08	3.25	1.30	7.73
Covid Exclusive	Overlap	0.98	1.93	1.77	1.75	1.74
R_Mild Exclusive	Overlap	0.99	1.96	1.65	2.04	1.67
Overlap	Exclusives	0.77	2.37	14.26	2.66	15.35

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	R_Mild	0.01	0.70	1.73	1.28	4.54
R_Mild Exclusive	Covid	0.01	-0.82	2.70	0.05	2.66
Covid Exclusive	R_Mild Exclusive	0.01	0.70	1.21	1.14	4.71
R_Mild Exclusive	Covid Exclusive	0.01	-0.96	1.92	0.04	5.37
Covid Exclusive	Overlap	0.00	6.78	0.42	6.14	0.38
R_Mild Exclusive	Overlap	0.00	7.48	14.02	25.06	11.62
Overlap	Exclusives	0.06	4.61	33.83	5.38	43.32

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid Exclusive	77	74	SRY;MBL3P;HLA-DRB4
R_Mild Exclusive	201	201	
Overlap	1	1