Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
JLC	R_Mild	1.07e-21	2.47e-03	4.27e-02	5.20e-03
R_Mild	JLC	1.73e-01	2.53e-01	6.33e-01	3.50e-03



Evaluating how well JLC genes are linked to R_Mild genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	R_Mild	0.54	-1.12	-3.64	-0.73	1.91
R_Mild	JLC	0.71	0.06	0.84	0.28	2.39

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	R_Mild	0.01	-0.76	-2.28	-0.58	0.37
R_Mild	JLC	0.00	-0.50	-0.23	-0.36	0.32

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
JLC	13	12	UNC93B
R_Mild	202	202