Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral Exclusive	R_Severe	3.98e-08	2.47e-02	1.71e-07	3.74e-09
R_Severe Exclusive	Viral	4.91e-03	2.08e-04	1.33e-05	2.75e-16
Viral Exclusive	R_Severe Exclusive	3.08e-08	2.00e-02	7.22e-07	1.51e-08
R_Severe Exclusive	Viral Exclusive	1.26e-02	6.34e-04	2.44e-05	8.35e-16
Viral Exclusive	Overlap	7.88e-02	1.05e-01	7.88e-02	1.02e-01
R_Severe Exclusive	Overlap	7.88e-02	7.88e-02	7.88e-02	1.05e-01
Overlap	Exclusives	2.87e-45	2.18e-34	3.15e-78	5.12e-64



Evaluating how well Viral genes are linked to R_Severe genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	R_Severe	0.63	2.12	3.19	2.16	7.08
R_Severe Exclusive	Viral	0.74	0.70	4.24	1.48	7.98
Viral Exclusive	R_Severe Exclusive	0.63	1.95	3.82	1.53	6.90
R_Severe Exclusive	Viral Exclusive	0.74	0.70	4.05	1.68	7.22
Viral Exclusive	Overlap	0.79	1.47	1.55	1.28	1.65
R_Severe Exclusive	Overlap	0.86	2.09	2.67	1.95	2.17
Overlap	Exclusives	0.79	4.09	14.85	3.06	15.64

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	R_Severe	0.02	1.77	2.46	1.79	5.92
R_Severe Exclusive	Viral	0.01	-0.59	4.13	0.46	8.27
Viral Exclusive	R_Severe Exclusive	0.02	1.56	2.23	1.44	4.08
R_Severe Exclusive	Viral Exclusive	0.01	-0.52	3.04	0.64	8.34
Viral Exclusive	Overlap	0.00	1.74	0.98	5.36	2.06
R_Severe Exclusive	Overlap	0.01	8.49	84.16	14.60	23.22
Overlap	Exclusives	0.06	9.11	39.09	7.37	40.64

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral Exclusive	105	101	HLA-DRB4;SRY;SNORA31;MBL3P
R_Severe Exclusive	209	209	
Overlap	3	3