Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
JLC	R_Severe	3.42e-17	3.22e-01	2.33e-01	1.28e-04
R_Severe	JLC	9.58e-02	2.12e-01	6.07e-01	3.01e-03



Evaluating how well JLC genes are linked to R_Severe genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	R_Severe	0.56	-0.57	-1.19	-0.31	2.81
R_Severe	JLC	0.70	0.08	0.62	0.02	2.15

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	R_Severe	0.01	-0.51	-1.08	-0.34	0.86
R_Severe	JLC	0.00	-0.56	-0.66	-0.50	0.20

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
JLC	13	12	UNC93B
R_Severe	212	212