Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
JLC	R_Severe	6.70e-08	7.40e-01	3.30e-01	1.52e-03
R_Severe	JLC	9.15e-01	5.87e-01	8.25e-02	6.16e-03



Evaluating how well JLC genes are linked to R_Severe genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	R_Severe	0.61	-0.30	-0.26	-0.01	4.36
R_Severe	JLC	0.77	0.62	1.43	0.87	3.23

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	R_Severe	0.01	-0.09	0.65	0.26	2.07
R_Severe	JLC	0.00	-0.27	-0.56	0.05	1.26

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
JLC	13	12	UNC93B
R_Severe	125	124	TFDP2