Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral Exclusive	R_Severe	2.94e-05	1.79e-02	1.40e-07	6.28e-08
R_Severe Exclusive	Viral	3.31e-05	2.24e-04	5.01e-11	3.15e-16
Viral Exclusive	R_Severe Exclusive	1.03e-04	1.86e-02	5.53e-07	5.17e-08
R_Severe Exclusive	Viral Exclusive	1.56e-04	8.39e-05	4.93e-11	7.54e-16
Viral Exclusive	Overlap	7.88e-02	7.88e-02	7.88e-02	1.08e-01
R_Severe Exclusive	Overlap	7.88e-02	7.88e-02	7.88e-02	8.96e-02
Overlap	Exclusives	2.32e-23	2.42e-23	6.19e-40	1.35e-39



Evaluating how well Viral genes are linked to R_Severe genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	R_Severe	0.67	1.84	3.43	2.01	5.72
R_Severe Exclusive	Viral	0.77	1.38	5.58	2.04	10.15
Viral Exclusive	R_Severe Exclusive	0.66	1.89	2.94	2.42	6.10
R_Severe Exclusive	Viral Exclusive	0.77	1.42	5.23	2.33	9.04
Viral Exclusive	Overlap	0.79	2.00	1.45	1.27	1.90
R_Severe Exclusive	Overlap	0.70	0.42	0.59	0.75	1.16
Overlap	Exclusives	0.79	2.35	11.52	2.38	16.40

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	R_Severe	0.01	1.71	4.67	2.81	8.56
R_Severe Exclusive	Viral	0.01	0.08	6.65	2.47	16.17
Viral Exclusive	R_Severe Exclusive	0.01	1.41	3.47	3.84	7.29
R_Severe Exclusive	Viral Exclusive	0.01	-0.02	6.42	1.97	5.94
Viral Exclusive	Overlap	0.00	25.99	28.36	10.55	8.76
R_Severe Exclusive	Overlap	0.00	2.97	10.55	6.41	6.63
Overlap	Exclusives	0.04	7.77	32.22	5.62	39.45

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral Exclusive	105	101	SNORA31;HLA-DRB4;SRY;MBL3P
R_Severe Exclusive	122	121	TFDP2
Overlap	3	3