Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral Exclusive	S_Control	7.46e-16	2.07e-01	6.52e-07	7.50e-03
S_Control Exclusive	Viral	1.10e-01	4.90e-02	1.90e-02	6.30e-12
Viral Exclusive	S_Control Exclusive	3.61e-16	3.54e-01	1.64e-06	7.17e-03
S_Control Exclusive	Viral Exclusive	1.19e-01	9.24e-02	8.53e-02	1.30e-10
Viral Exclusive	Overlap	7.88e-02	3.22e-02	9.60e-03	1.00e-02
S_Control Exclusive	Overlap	1.83e-01	8.68e-02	9.25e-02	3.22e-02
Overlap	Exclusives	1.05e-08	2.39e-09	8.78e-21	4.72e-17



Evaluating how well Viral genes are linked to S_Control genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	S_Control	0.55	2.36	1.97	1.75	3.49
S_Control Exclusive	Viral	0.73	1.28	2.84	1.01	7.57
Viral Exclusive	S_Control Exclusive	0.54	2.65	1.52	1.67	3.37
S_Control Exclusive	Viral Exclusive	0.72	1.16	3.23	0.65	7.37
Viral Exclusive	Overlap	0.94	2.68	2.86	2.57	2.51
S_Control Exclusive	Overlap	0.86	2.09	1.76	2.85	2.07
Overlap	Exclusives	0.62	2.22	7.65	1.94	10.11

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	S_Control	0.03	3.65	2.49	2.17	2.79
S_Control Exclusive	Viral	0.01	-0.02	3.31	0.37	12.18
Viral Exclusive	S_Control Exclusive	0.03	3.76	1.51	1.91	2.40
S_Control Exclusive	Viral Exclusive	0.01	0.07	3.55	0.12	11.47
Viral Exclusive	Overlap	0.01	21.05	23.89	7.36	11.73
S_Control Exclusive	Overlap	0.00	0.28	0.21	1.39	0.15
Overlap	Exclusives	0.06	5.47	18.06	4.87	21.54

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral Exclusive	105	101	HLA-DRB4;SNORA31;MBL3P;SRY
S_Control Exclusive	483	482	UGT2A1
Overlap	3	3