Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid Exclusive	S_Control	9.24e-14	2.83e-01	2.45e-06	7.20e-04
S_Control Exclusive	Covid	1.25e-01	2.77e-02	4.66e-02	4.27e-10
Covid Exclusive	S_Control Exclusive	6.56e-14	3.67e-01	3.39e-06	5.35e-04
S_Control Exclusive	Covid Exclusive	1.73e-01	3.73e-02	5.01e-02	1.76e-09
Covid Exclusive	Overlap	2.00e-02	5.74e-02	1.22e-02	6.25e-02
S_Control Exclusive	Overlap	3.37e-02	6.25e-02	1.65e-02	1.78e-01
Overlap	Exclusives	2.61e-06	1.65e-06	5.07e-11	1.60e-12



Evaluating how well Covid genes are linked to S_Control genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	S_Control	0.55	3.03	2.33	1.76	3.76
S_Control Exclusive	Covid	0.74	1.07	3.33	1.13	6.85
Covid Exclusive	S_Control Exclusive	0.55	3.20	1.99	1.69	3.92
S_Control Exclusive	Covid Exclusive	0.74	0.67	3.42	0.84	6.77
Covid Exclusive	Overlap	0.93	3.26	2.22	2.96	1.82
S_Control Exclusive	Overlap	0.80	2.17	1.47	2.67	1.22
Overlap	Exclusives	0.61	1.51	6.20	1.92	9.34

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	S_Control	0.03	3.78	2.38	1.94	2.89
S_Control Exclusive	Covid	0.01	-0.12	4.12	0.49	12.80
Covid Exclusive	S_Control Exclusive	0.03	3.69	2.09	1.94	3.04
S_Control Exclusive	Covid Exclusive	0.01	-0.29	5.03	0.24	14.65
Covid Exclusive	Overlap	0.00	50.72	2.03	57.96	2.41
S_Control Exclusive	Overlap	0.00	2.07	1.08	4.12	-0.00
Overlap	Exclusives	0.05	3.27	12.64	3.56	17.40

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid Exclusive	76	73	MBL3P;SRY;HLA-DRB4
S_Control Exclusive	484	483	UGT2A1
Overlap	2	2