Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
JLC	S_Control	1.13e-21	9.82e-01	1.57e-02	1.36e-03
S_Control	JLC	8.84e-01	9.69e-01	5.24e-01	1.75e-01



Evaluating how well JLC genes are linked to S_Control genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	S_Control	0.54	0.64	0.30	0.41	3.01
S_Control	JLC	0.65	-0.26	-0.49	-0.80	1.96

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	S_Control	0.03	0.53	0.14	0.18	1.16
S_Control	JLC	0.00	-0.63	-0.77	-0.65	0.34

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
JLC	13	12	UNC93B
S_Control	486	485	UGT2A1