Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral Exclusive	S_Control	2.45e-14	9.98e-02	1.39e-05	1.46e-02
S_Control Exclusive	Viral	3.12e-03	6.23e-04	4.02e-03	1.54e-16
Viral Exclusive	S_Control Exclusive	1.21e-14	1.26e-01	4.27e-05	2.33e-02
S_Control Exclusive	Viral Exclusive	7.56e-03	1.25e-03	3.76e-03	4.08e-15
Viral Exclusive	Overlap	7.88e-02	1.00e-02	1.13e-02	1.76e-02
S_Control Exclusive	Overlap	1.37e-01	4.60e-02	1.68e-01	1.90e-02
Overlap	Exclusives	2.16e-11	1.35e-10	6.34e-54	1.09e-14



Evaluating how well Viral genes are linked to S_Control genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	S_Control	0.54	2.82	2.94	2.36	3.23
S_Control Exclusive	Viral	0.75	1.84	3.89	1.58	8.86
Viral Exclusive	S_Control Exclusive	0.54	3.20	2.41	1.93	2.46
S_Control Exclusive	Viral Exclusive	0.75	1.73	4.00	1.47	8.63
Viral Exclusive	Overlap	0.93	2.27	2.63	2.37	2.60
S_Control Exclusive	Overlap	0.88	1.98	2.37	1.93	2.24
Overlap	Exclusives	0.63	2.89	8.24	2.48	9.85

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	S_Control	0.02	4.95	2.57	3.29	3.13
S_Control Exclusive	Viral	0.01	0.38	4.08	0.33	7.51
Viral Exclusive	S_Control Exclusive	0.02	4.79	1.75	2.07	2.09
S_Control Exclusive	Viral Exclusive	0.01	0.23	3.84	0.51	6.73
Viral Exclusive	Overlap	0.01	37.60	21.44	21.02	42.55
S_Control Exclusive	Overlap	0.00	0.99	3.37	0.69	1.71
Overlap	Exclusives	0.05	6.11	17.45	5.61	19.86

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral Exclusive	105	101	SRY;HLA-DRB4;SNORA31;MBL3P
S_Control Exclusive	393	392	UGT2A1
Overlap	3	3