Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid Exclusive	S_Control	3.48e-09	4.05e-02	1.16e-04	2.21e-03
S_Control Exclusive	Covid	1.45e-03	1.97e-04	4.94e-03	1.61e-15
Covid Exclusive	S_Control Exclusive	7.27e-09	3.22e-02	2.66e-04	3.27e-03
S_Control Exclusive	Covid Exclusive	7.21e-03	4.31e-04	8.45e-03	1.35e-13
Covid Exclusive	Overlap	7.88e-02	1.33e-02	7.15e-03	1.04e-02
S_Control Exclusive	Overlap	1.22e-01	4.44e-02	1.83e-01	2.68e-02
Overlap	Exclusives	2.00e-08	1.53e-07	1.13e-46	1.06e-10



Evaluating how well Covid genes are linked to S_Control genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	S_Control	0.55	3.11	3.15	2.02	3.18
S_Control Exclusive	Covid	0.78	2.08	4.50	1.59	7.79
Covid Exclusive	S_Control Exclusive	0.55	3.27	3.46	2.01	3.45
S_Control Exclusive	Covid Exclusive	0.77	2.00	4.01	1.67	8.24
Covid Exclusive	Overlap	0.94	2.74	2.44	2.49	2.99
S_Control Exclusive	Overlap	0.88	2.11	2.23	1.79	2.35
Overlap	Exclusives	0.61	2.86	7.56	2.27	8.60

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	S_Control	0.02	4.66	2.37	2.65	3.21
S_Control Exclusive	Covid	0.01	0.42	5.23	0.30	2.64
Covid Exclusive	S_Control Exclusive	0.02	4.38	2.73	2.45	2.86
S_Control Exclusive	Covid Exclusive	0.01	-0.03	4.84	0.44	9.89
Covid Exclusive	Overlap	0.01	18.74	11.32	7.71	14.52
S_Control Exclusive	Overlap	0.00	2.53	2.97	0.28	0.71
Overlap	Exclusives	0.04	6.94	17.37	4.00	17.82

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid Exclusive	75	72	MBL3P;SRY;HLA-DRB4
S_Control Exclusive	393	392	UGT2A1
Overlap	3	3