Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
JLC	S_Control	2.12e-17	5.87e-01	1.63e-02	8.98e-03
S_Control	JLC	6.98e-01	3.57e-01	7.43e-01	3.74e-03



Evaluating how well JLC genes are linked to S_Control genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	S_Control	0.53	0.72	1.06	0.45	2.03
S_Control	JLC	0.78	0.64	1.84	0.60	3.39

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	S_Control	0.02	0.64	0.56	0.19	0.69
S_Control	JLC	0.00	-0.15	-0.08	-0.15	2.68

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
JLC	13	12	UNC93B
S_Control	396	395	UGT2A1