Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
JLC	S_Control	2.68e-23	2.00e-01	8.63e-02	1.16e-01
S_Control	JLC	3.28e-02	7.41e-02	8.76e-02	8.10e-04



Evaluating how well JLC genes are linked to S_Control genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	S_Control	0.49	-0.75	-0.65	-0.62	-0.88
S_Control	JLC	0.81	1.41	2.29	1.21	3.63

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	S_Control	0.02	0.29	0.46	-0.08	-0.25
S_Control	JLC	0.00	0.42	1.52	0.38	2.18

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
JLC	13	12	UNC93B
S_Control	333	333