Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid Exclusive	S_Mild	8.09e-18	3.72e-01	2.67e-03	5.58e-01
S_Mild Exclusive	Covid	6.98e-04	3.71e-03	5.40e-03	6.70e-10
Covid Exclusive	S_Mild Exclusive	1.06e-16	3.70e-01	1.06e-03	4.48e-01
S_Mild Exclusive	Covid Exclusive	2.38e-04	2.76e-03	8.57e-03	2.78e-10
Covid Exclusive	Overlap	1.15e-02	1.28e-02	1.15e-02	1.28e-02
S_Mild Exclusive	Overlap	5.53e-01	5.40e-01	5.40e-01	6.47e-01
Overlap	Exclusives	3.78e-16	8.65e-05	1.70e-15	2.68e-06



Evaluating how well Covid genes are linked to S_Mild genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	S_Mild	0.49	-0.12	-0.64	-0.46	-0.87
S_Mild Exclusive	Covid	0.72	0.93	2.58	0.78	6.61
Covid Exclusive	S_Mild Exclusive	0.48	0.12	-0.90	-0.76	-1.04
S_Mild Exclusive	Covid Exclusive	0.73	1.03	3.16	0.83	6.77
Covid Exclusive	Overlap	0.99	2.61	3.24	2.93	2.50
S_Mild Exclusive	Overlap	0.30	-0.20	-1.01	-0.35	-0.79
Overlap	Exclusives	0.59	1.75	5.72	1.92	5.63

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	S_Mild	0.02	2.88	1.92	1.16	0.81
S_Mild Exclusive	Covid	0.01	-0.08	1.79	-0.09	7.04
Covid Exclusive	S_Mild Exclusive	0.02	2.32	1.38	0.37	0.29
S_Mild Exclusive	Covid Exclusive	0.01	0.04	2.17	-0.18	2.54
Covid Exclusive	Overlap	0.01	5.55	32.35	15.92	2.36
S_Mild Exclusive	Overlap	0.00	-0.35	-0.14	-0.45	-0.38
Overlap	Exclusives	0.04	4.52	13.28	3.49	11.61

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid Exclusive	76	73	SRY;MBL3P;HLA-DRB4
S_Mild Exclusive	331	331	
Overlap	2	2