Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral Exclusive	S_Mild	1.38e-18	5.43e-01	3.33e-04	5.73e-01
S_Mild Exclusive	Viral	1.94e-04	3.56e-02	2.23e-02	5.95e-10
Viral Exclusive	S_Mild Exclusive	9.29e-19	4.55e-01	1.63e-04	6.03e-01
S_Mild Exclusive	Viral Exclusive	3.55e-04	4.40e-02	3.96e-02	2.32e-11
Viral Exclusive	Overlap	1.15e-02	1.42e-02	1.15e-02	1.22e-02
S_Mild Exclusive	Overlap	5.40e-01	5.40e-01	5.40e-01	6.60e-01
Overlap	Exclusives	2.79e-13	1.25e-08	5.25e-13	4.62e-11



Evaluating how well Viral genes are linked to S_Mild genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	S_Mild	0.49	0.67	-0.05	0.07	-0.19
S_Mild Exclusive	Viral	0.71	1.44	2.78	0.83	6.69
Viral Exclusive	S_Mild Exclusive	0.49	0.56	-0.24	-0.31	-0.58
S_Mild Exclusive	Viral Exclusive	0.72	1.24	2.64	0.70	8.79
Viral Exclusive	Overlap	0.99	3.16	3.23	2.89	2.66
S_Mild Exclusive	Overlap	0.30	-0.12	-0.90	-0.34	-0.88
Overlap	Exclusives	0.61	2.41	6.30	1.94	8.12

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	S_Mild	0.02	3.51	1.75	1.12	0.88
S_Mild Exclusive	Viral	0.01	0.21	1.32	-0.09	3.19
Viral Exclusive	S_Mild Exclusive	0.02	3.29	0.96	0.60	0.31
S_Mild Exclusive	Viral Exclusive	0.01	0.27	1.42	-0.20	9.43
Viral Exclusive	Overlap	0.01	55.82	17.90	32.78	8.38
S_Mild Exclusive	Overlap	0.00	-0.30	-0.43	-0.41	-0.34
Overlap	Exclusives	0.05	5.96	17.05	4.67	23.30

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral Exclusive	106	102	SNORA31;MBL3P;HLA-DRB4;SRY
S_Mild Exclusive	331	331	
Overlap	2	2