Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
JLC	S_Mild	8.16e-24	1.11e-01	7.53e-02	1.63e-01
S_Mild	JLC	3.17e-02	8.63e-02	1.08e-01	6.38e-04



Evaluating how well JLC genes are linked to S_Mild genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	S_Mild	0.49	-0.69	-0.93	-0.60	-0.64
S_Mild	JLC	0.81	1.26	2.47	1.11	3.46

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	S_Mild	0.02	0.34	0.36	-0.04	-0.10
S_Mild	JLC	0.00	0.33	1.68	0.44	2.46

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
JLC	13	12	UNC93B
S_Mild	333	333