Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral Exclusive	S_Mild	4.48e-16	5.63e-01	9.61e-04	4.26e-01
S_Mild Exclusive	Viral	3.11e-01	1.15e-01	3.02e-01	9.41e-11
Viral Exclusive	S_Mild Exclusive	3.45e-16	8.07e-01	2.11e-03	4.61e-01
S_Mild Exclusive	Viral Exclusive	5.70e-01	1.63e-01	2.60e-01	1.29e-10
Viral Exclusive	Overlap	2.75e-01	5.79e-01	1.22e-02	2.80e-02
S_Mild Exclusive	Overlap	6.20e-01	5.40e-01	6.20e-01	2.04e-01
Overlap	Exclusives	1.45e-02	9.26e-12	8.34e-48	3.10e-15



Evaluating how well Viral genes are linked to S_Mild genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	S_Mild	0.53	0.47	0.06	0.62	1.73
S_Mild Exclusive	Viral	0.70	0.70	1.67	0.55	7.14
Viral Exclusive	S_Mild Exclusive	0.52	0.39	-0.37	0.33	1.53
S_Mild Exclusive	Viral Exclusive	0.70	0.75	1.58	0.70	7.24
Viral Exclusive	Overlap	0.95	5.62	1.46	2.40	2.47
S_Mild Exclusive	Overlap	0.82	2.04	0.94	1.76	1.57
Overlap	Exclusives	0.65	4.36	7.69	2.81	9.86

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	S_Mild	0.02	1.44	0.46	1.18	1.32
S_Mild Exclusive	Viral	0.01	-0.18	0.44	-0.16	7.78
Viral Exclusive	S_Mild Exclusive	0.02	1.20	-0.17	0.67	0.93
S_Mild Exclusive	Viral Exclusive	0.01	-0.09	0.31	-0.10	5.92
Viral Exclusive	Overlap	0.01	4.28	0.92	17.54	1.91
S_Mild Exclusive	Overlap	0.00	-0.06	2.50	0.29	0.91
Overlap	Exclusives	0.04	3.08	17.74	5.94	22.38

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral Exclusive	106	102	SNORA31;SRY;HLA-DRB4;MBL3P
S_Mild Exclusive	279	279	
Overlap	2	2