Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid Exclusive	S_Mild	2.24e-09	5.96e-01	8.00e-04	8.81e-02
S_Mild Exclusive	Covid	5.06e-01	8.16e-02	1.45e-01	1.95e-10
Covid Exclusive	S_Mild Exclusive	6.11e-10	6.51e-01	1.42e-03	1.15e-01
S_Mild Exclusive	Covid Exclusive	7.34e-01	1.03e-01	2.32e-01	2.08e-10
Covid Exclusive	Overlap	9.92e-02	2.06e-01	9.92e-02	1.66e-01
S_Mild Exclusive	Overlap	1.41e-01	2.40e-01	1.49e-01	6.11e-01
Overlap	Exclusives	6.55e-03	1.15e-03	2.86e-04	2.98e-08



Evaluating how well Covid genes are linked to S_Mild genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	S_Mild	0.53	1.60	0.61	1.03	2.06
S_Mild Exclusive	Covid	0.73	0.87	2.50	0.95	6.48
Covid Exclusive	S_Mild Exclusive	0.53	0.94	0.65	0.76	1.77
S_Mild Exclusive	Covid Exclusive	0.73	0.56	2.37	0.85	7.43
Covid Exclusive	Overlap	0.93	6.49	1.49	1.76	1.44
S_Mild Exclusive	Overlap	0.66	2.12	1.17	1.74	0.51
Overlap	Exclusives	0.59	1.16	3.93	1.16	5.89

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	S_Mild	0.02	2.15	0.43	1.38	1.07
S_Mild Exclusive	Covid	0.01	-0.13	2.48	0.23	2.26
Covid Exclusive	S_Mild Exclusive	0.02	1.40	0.51	1.19	1.05
S_Mild Exclusive	Covid Exclusive	0.01	-0.27	2.21	0.12	9.41
Covid Exclusive	Overlap	0.00	53.03	-0.05	0.42	0.30
S_Mild Exclusive	Overlap	0.00	2.41	-0.10	1.48	-0.11
Overlap	Exclusives	0.03	0.91	4.73	1.26	6.68

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid Exclusive	77	74	HLA-DRB4;SRY;MBL3P
S_Mild Exclusive	280	280	
Overlap	1	1