Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
JLC	S_Mild	1.76e-13	4.88e-01	2.91e-02	2.46e-01
S_Mild	JLC	5.09e-01	6.98e-01	2.85e-01	3.23e-02



Evaluating how well JLC genes are linked to S_Mild genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	S_Mild	0.52	-0.57	-0.17	-0.14	1.46
S_Mild	JLC	0.74	0.46	0.82	0.37	2.91

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	S_Mild	0.02	-0.24	-0.11	0.10	0.62
S_Mild	JLC	0.00	-0.15	-0.25	-0.15	1.18

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
JLC	13	12	UNC93B
S_Mild	281	281