Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral Exclusive	S_Severe	1.28e-17	3.64e-02	2.30e-08	1.38e-01
S_Severe Exclusive	Viral	6.20e-08	4.98e-07	4.27e-07	2.13e-20
Viral Exclusive	S_Severe Exclusive	1.08e-17	5.93e-02	4.88e-08	1.62e-01
S_Severe Exclusive	Viral Exclusive	2.14e-08	6.13e-07	3.73e-07	1.21e-20
Viral Exclusive	Overlap	7.88e-02	1.54e-01	8.14e-02	1.59e-01
S_Severe Exclusive	Overlap	3.08e-01	6.70e-01	4.53e-01	9.32e-01
Overlap	Exclusives	9.89e-09	2.02e-09	9.64e-06	6.60e-11



Evaluating how well Viral genes are linked to S_Severe genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	S_Severe	0.53	2.72	2.42	1.63	2.21
S_Severe Exclusive	Viral	0.79	3.08	5.84	2.32	11.46
Viral Exclusive	S_Severe Exclusive	0.53	2.54	2.33	1.90	2.30
S_Severe Exclusive	Viral Exclusive	0.80	3.12	5.81	2.58	9.73
Viral Exclusive	Overlap	0.77	5.69	2.10	2.35	1.78
S_Severe Exclusive	Overlap	0.47	1.18	0.24	0.74	-0.25
Overlap	Exclusives	0.60	1.88	6.67	1.86	8.05

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	S_Severe	0.03	7.34	6.30	3.60	3.75
S_Severe Exclusive	Viral	0.02	3.13	8.05	3.04	11.61
Viral Exclusive	S_Severe Exclusive	0.03	5.16	4.39	3.50	3.88
S_Severe Exclusive	Viral Exclusive	0.02	3.77	10.92	2.41	29.53
Viral Exclusive	Overlap	0.01	546.38	7.56	34.03	28.32
S_Severe Exclusive	Overlap	0.00	0.22	-0.26	0.37	-0.29
Overlap	Exclusives	0.05	3.87	14.76	3.57	16.36

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral Exclusive	105	101	HLA-DRB4;SRY;SNORA31;MBL3P
S_Severe Exclusive	445	445	
Overlap	3	3