Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid Exclusive	S_Severe	2.22e-16	5.91e-02	3.91e-07	1.70e-01
S_Severe Exclusive	Covid	2.33e-09	9.11e-07	2.10e-08	7.80e-19
Covid Exclusive	S_Severe Exclusive	5.77e-16	6.49e-02	6.55e-07	2.12e-01
S_Severe Exclusive	Covid Exclusive	1.58e-09	5.06e-07	3.15e-08	2.17e-18
Covid Exclusive	Overlap	1.49e-01	2.58e-01	2.84e-01	6.20e-01
S_Severe Exclusive	Overlap	5.66e-01	7.66e-01	6.20e-01	8.51e-01
Overlap	Exclusives	6.98e-02	2.85e-01	5.74e-07	9.36e-03



Evaluating how well Covid genes are linked to S_Severe genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	S_Severe	0.53	2.54	2.31	1.82	2.23
S_Severe Exclusive	Covid	0.81	3.03	6.24	2.75	9.50
Covid Exclusive	S_Severe Exclusive	0.53	2.68	2.28	1.81	2.06
S_Severe Exclusive	Covid Exclusive	0.82	3.21	7.43	2.73	8.80
Covid Exclusive	Overlap	0.72	5.07	1.62	1.62	0.96
S_Severe Exclusive	Overlap	0.42	0.73	-0.07	0.48	-0.28
Overlap	Exclusives	0.54	0.36	1.55	0.40	3.44

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	S_Severe	0.03	5.32	5.68	3.98	4.58
S_Severe Exclusive	Covid	0.02	4.10	13.46	4.22	9.25
Covid Exclusive	S_Severe Exclusive	0.03	6.49	5.63	4.26	4.26
S_Severe Exclusive	Covid Exclusive	0.02	5.04	13.94	4.05	30.31
Covid Exclusive	Overlap	0.00	13.67	1.83	0.49	0.30
S_Severe Exclusive	Overlap	0.00	0.65	-0.29	0.10	-0.42
Overlap	Exclusives	0.03	0.23	2.17	0.34	2.92

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid Exclusive	76	73	HLA-DRB4;MBL3P;SRY
S_Severe Exclusive	446	446	
Overlap	2	2