Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
JLC Exclusive	S_Severe	2.01e-15	7.53e-01	2.37e-05	7.92e-02
S_Severe Exclusive	JLC	9.44e-02	1.94e-01	1.87e-01	7.54e-04
JLC Exclusive	S_Severe Exclusive	6.31e-16	7.88e-01	8.45e-05	8.40e-02
S_Severe Exclusive	JLC Exclusive	8.40e-02	1.58e-01	1.71e-01	1.47e-03
JLC Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
S_Severe Exclusive	Overlap	4.35e-01	2.92e-01	5.30e-01	6.11e-01
Overlap	Exclusives	1.95e-15	3.91e-02	2.39e-12	9.07e-02



Evaluating how well JLC genes are linked to S_Severe genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC Exclusive	S_Severe	0.52	1.03	0.80	0.71	1.16
S_Severe Exclusive	JLC	0.80	1.48	2.41	0.87	3.39
JLC Exclusive	S_Severe Exclusive	0.51	0.99	0.67	0.47	1.07
S_Severe Exclusive	JLC Exclusive	0.82	1.30	2.00	0.79	3.69
JLC Exclusive	Overlap	1.00	3.00	1.97	1.99	1.76
S_Severe Exclusive	Overlap	0.57	0.76	0.65	0.54	0.34
Overlap	Exclusives	0.53	0.39	2.31	0.76	2.22

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC Exclusive	S_Severe	0.02	1.56	1.84	1.14	1.26
S_Severe Exclusive	JLC	0.00	0.97	2.30	0.42	2.67
JLC Exclusive	S_Severe Exclusive	0.02	1.35	1.46	0.63	0.76
S_Severe Exclusive	JLC Exclusive	0.00	1.04	1.89	0.28	1.16
JLC Exclusive	Overlap	0.05	1446.43	554.72	31.85	88.28
S_Severe Exclusive	Overlap	0.00	0.00	-0.14	-0.17	-0.16
Overlap	Exclusives	0.03	1.37	5.08	1.75	4.39

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
JLC Exclusive	12	11	UNC93B
S_Severe Exclusive	447	447	
Overlap	1	1