Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid Exclusive	S_Severe	6.42e-17	7.30e-01	1.15e-03	6.81e-01
S_Severe Exclusive	Covid	5.55e-01	7.99e-01	5.55e-01	2.03e-05
Covid Exclusive	S_Severe Exclusive	7.04e-17	5.60e-01	7.30e-04	7.15e-01
S_Severe Exclusive	Covid Exclusive	4.40e-01	7.11e-01	4.28e-01	6.59e-06
Covid Exclusive	Overlap	1.72e-01	3.83e-01	4.28e-01	3.62e-01
S_Severe Exclusive	Overlap	3.12e-01	5.27e-01	2.66e-01	5.27e-01
Overlap	Exclusives	5.73e-02	1.51e-01	8.90e-06	3.05e-04



Evaluating how well Covid genes are linked to S_Severe genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	S_Severe	0.51	0.00	-0.42	-0.26	0.31
S_Severe Exclusive	Covid	0.65	-0.34	-0.25	-0.36	4.46
Covid Exclusive	S_Severe Exclusive	0.50	-0.26	-0.77	-0.57	0.10
S_Severe Exclusive	Covid Exclusive	0.65	-0.32	-0.37	-0.54	4.77
Covid Exclusive	Overlap	0.72	3.96	1.36	1.36	1.43
S_Severe Exclusive	Overlap	0.62	1.50	0.68	1.50	0.69
Overlap	Exclusives	0.57	0.59	2.17	0.31	4.46

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	S_Severe	0.01	0.84	-0.05	-0.20	-0.01
S_Severe Exclusive	Covid	0.01	-0.69	-0.74	-0.60	2.53
Covid Exclusive	S_Severe Exclusive	0.01	0.77	-0.34	-0.39	-0.14
S_Severe Exclusive	Covid Exclusive	0.01	-0.65	-0.59	-0.53	3.82
Covid Exclusive	Overlap	0.00	14.61	-0.11	0.32	0.02
S_Severe Exclusive	Overlap	0.00	0.73	-0.19	0.10	-0.26
Overlap	Exclusives	0.02	0.65	3.29	0.41	4.52

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid Exclusive	76	73	SRY;HLA-DRB4;MBL3P
S_Severe Exclusive	249	247	REXO5;PRAMEF11
Overlap	2	2