Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid	2MethodOverlap	4.98e-01	3.44e-01	1.66e-01	4.94e-02
2MethodOverlap	Covid	2.94e-02	4.06e-03	6.43e-16	1.05e-11



Evaluating how well Covid genes are linked to 2MethodOverlap genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	2MethodOverlap	0.75	-0.96	-0.43	0.29	2.44
2MethodOverlap	Covid	0.74	0.70	2.64	0.78	6.52

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	2MethodOverlap	0.00	-0.53	0.09	0.25	0.95
2MethodOverlap	Covid	0.01	0.09	0.70	0.46	7.33

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid	78	75	MBL3P;HLA-DRB4;SRY
2MethodOverlap	8	8