Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ViralGS Exclusive	SM_Over_01	3.66e-02	2.17e-01	7.12e-05	1.35e-05
SM_Over_01 Exclusive	ViralGS	2.37e-02	3.83e-02	9.51e-10	3.86e-12
ViralGS Exclusive	SM_Over_01 Exclusive	5.85e-02	1.89e-01	2.52e-04	2.49e-05
SM_Over_01 Exclusive	ViralGS Exclusive	1.28e-02	2.56e-02	1.63e-09	1.15e-11
ViralGS Exclusive	Overlap	5.40e-01	6.33e-01	5.40e-01	6.20e-01
SM_Over_01 Exclusive	Overlap	5.40e-01	6.33e-01	6.20e-01	6.06e-01
Overlap	Exclusives	5.09e-04	7.06e-06	2.35e-15	1.33e-18



Evaluating how well ViralGS genes are linked to SM_Over_01 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ViralGS Exclusive	SM_Over_01	0.70	1.43	1.89	1.93	4.79
SM_Over_01 Exclusive	ViralGS	0.73	0.93	3.46	1.34	9.03
ViralGS Exclusive	SM_Over_01 Exclusive	0.70	0.91	2.05	1.76	4.29
SM_Over_01 Exclusive	ViralGS Exclusive	0.73	1.12	3.69	1.42	7.71
ViralGS Exclusive	Overlap	0.69	1.02	0.61	0.48	1.03
SM_Over_01 Exclusive	Overlap	0.56	-0.15	-0.40	-0.12	0.41
Overlap	Exclusives	0.74	0.79	6.30	1.39	9.24

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ViralGS Exclusive	SM_Over_01	0.01	-0.32	2.41	2.92	0.71
SM_Over_01 Exclusive	ViralGS	0.02	0.80	4.77	2.26	16.50
ViralGS Exclusive	SM_Over_01 Exclusive	0.00	-0.30	2.42	2.19	2.98
SM_Over_01 Exclusive	ViralGS Exclusive	0.01	1.11	5.04	2.60	13.96
ViralGS Exclusive	Overlap	0.00	0.04	-0.02	0.72	0.74
SM_Over_01 Exclusive	Overlap	0.00	0.36	0.38	0.25	1.57
Overlap	Exclusives	0.02	0.37	8.43	1.37	11.56

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ViralGS Exclusive	106	102	MBL3P;SNORA31;SRY;HLA-DRB4
SM_Over_01 Exclusive	44	44	
Overlap	2	2